Sperm phospholipase C signaling via PLCζ1 and PLCδ4 is essential for Ca2+ oscillations and fertility in mice
The sperm-specific phospholipase C isoform PLCζ1 initiates fertilization Ca2+ oscillations in mammals, yet its loss causes only subfertility. This study shows that while PLCζ1 is the primary oscillator, PLCδ4 is a crucial backup oscillator, constituting a dua…